OLEH V. LUSHCHAK, PhD, Associate Professor
AFFILIATION
Associate professor at the Department of Biochemistry and Biotechnology in Precarpathian National University (Ivano-Frankivsk, Ukraine) and Visiting Professor at Tissue regeneration and aging group, Ludwig Boltzmann Institute for Experimental und Clinical Traumatology (Vienna, Austria)
Е-mail: oleh.lushchak@pnu.edu.ua
PERSONAL
Ukrainian, male, born May 22, 1983.
Home address: 129A Sechenova str, 36 block, apt 32A, Ivano-Frankivsk, 76492, Ukraine
Languages – English (Fluent), Portuguese (A0), German (A0)
EDUCATION
2004 – Bachelor’s degree in Biochemistry, Precarpathian University, Ivano-Frankivsk, Ukraine
2005 – Master’s degree in Biochemistry, Precarpathian University, Ivano-Frankivsk, Ukraine
2009 – PhD degree in Biochemistry, Precarpathian University, Ivano-Frankivsk, Ukraine
RESEARCH EXPERIENCE AND PRACTICAL TRAININGS
2000-9 – Department of Biochemistry and Biotechnology, Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine.
2002 – INTAS fellow “Growth dynamics in mollusks in natural environment”, Institute of Marine Biology, Kotor, Montenegro.
2003 – DAAD research fellow “Regulation of NADH oscillations in yeast”, Department of Biophysics, Otto-von-Gurike University, Magdeburg, Germany.
2009 – JEB research fellow “Rhodiola rosea as learning enhancer in D. melanogaster”, Department of Neurobiology and Genetics, University of Wurzburg, Wurzburg, Germany.
2009 – Visiting scientist “Mechanisms of lifespan extension by dietary restriction in D. melanogaster”, Buck Institute for Age Research, Novato, CA, USA.
2010 – Visiting scientist “Modulation of fly learning by natural chemicals”, Department of Neurobiology and Genetics, University of Wurzburg, Wurzburg, Germany.
2011-13 – Postdoc position supported by Carl Trygger Foundation “Food odors trigger an endocrine response that affects appetite, metabolism and lifespan”, Department of Zoology, Stockholm University, Stockholm, Sweden.
2012 – Visiting scientist “Mechanisms of lifespan and metabolism regulation by mitochondria”, Institute of Biomedical Technology, University of Tampere, Tampere, Finland.
2013-2014 – Visiting scientist “Nutrition, tissue homeostasis and aging in fruit fly”, DKFZ-ZMBH Alliance, Heidelberg, Germany.
2014-2018 – Assistant Professor at Vasyl Stefanyk Precarpathian National University
2015-2016 – Guest scientist “Epigenetic regulation of metabolism” Max-Planck-Institute of Immunology and Epigenetics, Freiburg, Germany.
2016-present – Head of laboratory “Aging and age-related disease”, Department of Biochemistry and Biotechnology, Precarpathian National University.
2020-present – Director of Collaborative center for Aging research, Ivano-Frankivsk, Ukraine.
2018-2020 – Associate professor in Biochemistry at Precarpathian National University.
2022-present – Professor at Precarpathian National University.
2022-present – Visiting Professor at Ludwig Boltzmann Institute for Clinical and Experimental Traumatology, Vienna, Austria.
AWARDS AND GRANTS
2022 – FEBS Ukrainian Short-Term Fellowships
2021 – Grant from National Research Foundation of Ukraine, Co-Principal investigator (160K Euro)
2020 – Grant from National Research Foundation of Ukraine, Co-Principal investigator (180K Euro)
2020 – Grant from National Research Foundation of Ukraine, Co-Principal investigator (220K Euro)
2019 – Travel grant award from US-Ukraine Foundation (4K Euro)
2018 – 40 under 40 in biotechnology award from US-Ukraine Foundation (2K Euro)
2018-2019 – Stipend of President for the young scientists (10K Euro)
2017-2018 – Research grant from STCU-MESU, Principal investigator (120K Euro)
2017-2020 – Research grant for young scientists from MESU, Principal investigator (90K Euro)
2016 – Initiation of collaboration grant from DFG, Co-Principal investigator (20K Euro)
2015 – Albert Renold Fellowship from EFSD (8K Euro)
2014-16 – Stipend from Cabinet of Ministers of Ukraine (7K Euro).
2013 – Platon Kostyuk Award from Ukrainian Society for Neuroscience (2K Euro).
2013 – Best Young Scientist of Vasyl Stefanyk Precarpathian National University.
2008 – Travel Fellowship grant from Journal of Experimental Biology (3K Euro)
2007-8 – SFFI grant of MESU, Project leader (10K Euro)
2006 – Award for the best poster in “IX Congress of Ukrainian Biochemical Society” (200 Euro).
TEACHING
Associate Professor in Biochemistry
Courses: Molecular Biology, Introduction into Experimental Biology, Models in Aging Research, Analytical Biochemistry, Basic Principles of Scientific Research
INDUSTRY
Audubon bioscience
CSD laboratory
Diameb
REVIEWER
Aging Cell, Journal of Gerontology, Experimental Gerontology, Nature Communications, Cell Metabolism, Mechanisms of Aging and Development, Journal of Comparative Physiology, PLoS One, PLos Genetics, Open Biology, Chemico-biological Interactions, Redox Reports, Proceedings of the Royal Society, Cancer Research, Entomologia Experimentalis et Applicata, Biogerontology and others
CURRENT AREAS OF RESEARCH
– Nutrition and metabolism regulation;
– Signaling in regulation of aging;
– Age-related complications and pathologies;
– Epigenetic regulation in aging and metabolism;
– Microbiome, aging and metabolism;
– Personalized medicine;
EDITORIAL BOARDS
Biogerontology
Biochemistry and Physiology
Frontiers in Genetics – Genetics of Aging
Guest associate editor – Frontiers in Physiology, The Physiological Regulation of Energy Metabolism in Insects part I and II
MEMBERSHIP
Ukrainian Biochemical Society
European Foundation for the Study of Diabetes
PUBLICATIONS SUMMARY
Experimental papers – 88; Reviews – 32; Book chapters – 12; Patents – 5.
BIBLIOMETRICS
September 2022: Scopus h-index – 31, Citations – 3585; Google Scholar h-index – 37, Citations – 5154.
* – corresponding author
** – co-corresponding author
Articles
88. Vatashchuk M., Gospodaryov D., Hurza V., Demianchuk O., Ivanochko M., Burdyliuk N., Storey K., Lushchak O., Lushchak V., Bayliak M. High fat high fructose diet induces mild oxidative stress and reorganizes intermediary metabolism in male mouse liver: -ketoglutarate effects. Biochim. Biophys. Gen. Subj., 2022. in press.
87. Strilbytska O., Semaniuk U., Bubalo V., Storey K., Lushchak O.* Dietary choice reshape metabolism in Drosophila by affecting consumption of macronutrients. Biomolecules, 2022. in press.
86. Semaniuk U., Gospodaryov D., Strilbytska O., Kucharska A., Sokół-Łętowska A., Burdyliuk N., Storey K., Bayliak M., Lushchak O.* Chili-supplemented food decreases glutathione-S-transferase activity in Drosophila melanogaster females without a change in other parameters of antioxidant system. Redox Report, 2022. in press.
85. Strilbyska O., Semaniuk U., Strutynska T., Burdyliuk N., Tsiumpala S., Bubalo V., Lushchak O.* Herbicide Roundup shows toxic effects in nontarget organism Drosophila. Arch. Insect Biochem. Physiol., 2022. 110(4), e21893.
84. Strilbytska O., Semaniuk U., Burdyliyk N., Bubalo V., Lushchak O.* Developmental diet defines metabolic traits in larvae and adult Drosophila. Ukr Biochem J. 2022, 94(1), 53-63.
83. Semaniuk U., Gospodaryov D., Strilbytska O., Kucharska A., Sokół-Łętowska A., Burdyliuk N., Storey K., Bayliak M., Lushchak O.* Chili pepper extends lifespan in a concentration-dependent manner and confers cold resistance on Drosophila melanogaster cohorts by influencing specific metabolic pathways. Food Funct. 2022. 13(15), 8313-8328.
82. Falfushynska H., Khatib I., Kasianchuk N., Lushchak O., Horyn O., Sokolova I. Toxic effects and mechanisms of common organophosphate pesticides (Roundup and chlorpyrifos) and their mixtures in a zebrafish model (Danio rerio). Sci. Tot. Env. 2022. 833, 155236.
81. Strilbyska O., Semaniuk U., Burdyliuk N., Lushchak O. Evaluation of biological effects of graphene oxide using Drosophila. Phys. Chem. Solid State. 2022. 23 (2), 242-248.
80. Strilbytska O., Semaniuk U., Burdyliuk N., Lushchak O.** Protein content in the parental diet affects cold tolerance and oxidative stress markers in the offspring Drosophila. Ukr Biochem J. 2022, 94(1), 86-94.
79. Husak V., Strutynska T., Burdyliuk N., Pitukh A., Bubalo V., Falfushynska H., Strilbytska O., Lushchak O*. Low-toxic herbicides Roundup and Atrazine disturb free radical processes in Daphnia in environmentally relevant concentrations EXCLI J. 2022, 21:595-609.
78. Kuzub N., Smialkovska V., Momot V., Moseiko V., Lushchak O., Koliada A. Evaluation of Epigenetic Age Based on DNA Methylation Analysis of Several CpG Sites in Ukrainian Population. Front Genet. 2022, 12:772298.
77. Strilbyska O., Strutynska T., Semaniuk U., Burdyliuk N., Bubalo V., Lushchak O**. Dietary sucrose determines stress resistance, oxidative damages and antioxidant defense system in Drosophila. Scientifica. 2022, 7262342.
76. Strilbytska O., Zayachkivska A., Strutynska T., Semaniuk U., Vaiserman A., Lushchak O.** Dietary protein defines stress resistance, oxidative damages and antioxidant defense system in Drosophila melanogaster. Ukr Biochem J. 2021, 93(5), 90-101.
75. Strilbytska O., Stefanyshyn N., Semaniuk U., Lushchak O.** Yeast concentration in the diet defines Drosophila metabolism of both parental and offspring generations. Ukr Biochem J. 2021, 93(6), 119-129.
74. Mykhailovych V., Kanak A., Cojocaru R., Chitoiu-Arsene E., Palamaru M., Iordan A., Korovyanko O., Diaconu A., Ciobanu V., Caruntu G., Lushchak O., Fochuk P., Khalavka Y., Rotaru A. Structural, Optical, and Catalytic Properties of MgCr2O4 Spinel-Type Nanostructures Synthesized by Sol–Gel Auto-Combustion Method. Catalysts. 2021, 12:1476.
73. Koliada A., Moseiko V., Romanenko M., Lushchak O., Kryzhanovska N., Guryanov V., Vaiserman A. Sex differences in the phylum-level human gut microbiota composition. BMC Microbiol. 2021, 21(1):131.
72. Semaniuk U, Gospodaryov D, Mishchanyn K, Storey K, Lushchak O*. Drosophila insulin-like peptides regulate concentration-dependent changes of appetite to different carbohydrates. Zoology (Jena). 2021, 146:125927.
71. Strilbytska O., Strutynska T., Semaniuk U., Burdyliuk N., Storey K., Lushchak O. Parental dietary sucrose affects metabolic and antioxidant enzyme activities in Drosophila. Entomological science. 2021, in press.
70. Bulyhina T., Zdorovenko E., Varbanets L., Shashkov A., Kadykova A., Knirel Y., Lushchak O. Structure of O-Polysaccharide and Lipid A of Pantoea Agglomerans 8488. Biomolecules. 2020, 10(5):804.
69. Vaiserman A., Romanenko M., Piven L., Moseiko V., Lushchak O., Kryzhanovska N., Guryanov V., Koliada A. Differences in the gut Firmicutes to Bacteroidetes ratio across age groups in healthy Ukrainian population. BMC Microbiol. 2020, 20(1):221.
68. Strilbytska O., Zayachkivska A., Koliada A., Galeotti F., Volpi N., Storey K., Vaiserman A., Lushchak O. Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila. Front Physiol. 2020, 11:596729.
67. Koliada A., Moseiko V., Romanenko M., Piven L., Lushchak O., Kryzhanovska N., Guryanov V., Vaiserman A. Seasonal variation in gut microbiota composition: cross-sectional evidence from Ukrainian population. BMC Microbiol., 2020, 20, 100.
66. Strilbytska O., Strutynska T., Semaniuk U., Burdyliyk O., Lushchak O.* Dietary sucrose defines Drosophila lifespan and metabolism. Ukr Biochem J, 2020, 92(5), 97-105.
65. Yurkevych I., Gray L., Gospodaryov D., Burdyliuk N., Storey K., Simpson S., Lushchak O.* Development of fly tolerance to consuming a high-protein diet requires physiological, metabolic and transcriptional changes. Biogerontology, 2020, 21(5), 619-636.
64. Koliada A., Gavrilyuk K., Burdyliuk N., Strilbytska O., Storey K., Kuharskii V., Lushchak O., Vaiserman A. Mating status affects Drosophila lifespan, metabolism and antioxidant system. Comp. Biochem. Physiol. A., 2020, 246, 110716.
63. Strilbytska O., Storey K., Lushchak O.* TOR signaling inhibition in intestinal stem and progenitor cells affects physiology and metabolism in Drosophila. Comp. Biochem. Physiol. B., 2020. in press.
62. Strilbytska O., Semaniuk U., Storey K., Yurkevych I., Lushchak O.* Insulin signaling in intestinal stem and progenitor cells as an important determinant of physiological and metabolic traits in Drosophila. Cells, 2020. 9 (4), 803.
61. Gospodaryov D., Strilbytska O., Semaniuk U., Perkhulyn N., Rovenko B., Yurkevych I., Barata AG, Dick TP, Lushchak O, Jacobs HT. Alternative NADH dehydrogenase extends lifespan and increases resistance to xenobiotics in Drosophila. Biogerontology, 2020, 21,155-171.
60. Strilbytska O., Velianyk V., Burdyliuk N., Yurkevych I., Vaiserman A., Storey K., Pospisilik A., Lushchak O.* Parental dietary protein-to-carbohydrate ratio affects offspring lifespan and metabolism in drosophila. Comp. Biochem. Physiol. A., 2020. in press.
59. Bashynska V., Koliada A., Murlanova K., Zahorodnia O., Borysovych O., Moseiko V., Lushchak O., Vaiserman A. Prevalence of Some Genetic Risk Factors for Nicotine Dependence in Ukraine. Genetics Research International. 2019, 2483270.
58. Lushchak O., Karaman H., Kozeretska I., Koliada A., Zabuga O., Pisaruk A., Koshel N., Mechova L., Inomistova M., Khranovska N., Vaiserman A. Larval crowding results in hormesis-like effects on longevity in Drosophila: timing of eclosion as a model. Biogerontology. 2019, 20, 191-201.
57. Gubina N., Naudi A., Stefanatos R., Jove M., Scialo F., Fernandez-Ayala D., Rantapero T., Yurkevych I., Portero-Otin M., Nykter M., Lushchak O., Navas P., Pamplona R., Alberto Sanz Essential physiological differences characterize short and long-lived strains of Drosophila melanogaster. J Gerontol., 2019, 74, 1835-1843.
56. Michels B., Zwaka H., Bartels R., Lushchak O., Franke K., Endres T., Fendt M., Song I., Bakr M., Budragchaa T., Westermann B., Mishra D., Eschbach C., Schreyer S., Lingnau A., Vahl C., Hilker M., Menzel R., Kähne T., Leßmann V., Dityatev A., Wessjohann L., Gerber B. Memory enhancement by ferulic acid ester across species. Sci. Adv., 2018, 4, eaat6994.
55. Semaniuk U., Gospodaryov D., Feden’ko K., Yurkevych I., Vaiserman A., Storey K., Simpson SJ., Lushchak O.* (2018) Insulin-Like Peptides Regulate Feeding Preference and Metabolism in Drosophila. Front. Physiol. 2018, 9:1083.
54. Nuzhyna N., Baglay K., Golubenko A., Lushchak O. Anatomically distinct representatives of Cactaceae Juss. family have different response to acute heat shock stress. Flora, 2018, 242, 137-145.
53. Semaniuk U., Feden’ko K., Yurkevych I., Storey K., Simpson S., Lushchak O*. Within-diet variation in rates of macronutrien consumption and reproduction do not accompany changes in lifespan in Drosophila melanogaster. Entomol. Exp. Appl., 2018, 166(1), 74-80.
52. Strilbytska O., Koliada A., Storey K., Mudra S., Vaiserman A., Lushchak O*. Longevity and stress resistance are affected by activation of TOR/Myc in progenitor cells of drosophila gut. Open Life Sci., 2017, 12(1), 429-442.
51. Koliada A., Syzenko G., Moseiko V., Budovska L., Puchkov K., Perederiy V., Gavalko Y., Dorofeyev A., Romanenko M., Tkach S., Sineok L., Lushchak O., Vaiserman A. Association between body mass index and Firmicutes/Bacteroidetes ratio in an adult Ukrainian population. BMC Microbiol., 2017, 17(1), 120.
50. Perkhulyn N., Rovenko B., Lushchak O., Storey J., Storey K., Lushchak V. Exposure to sodium molybdate results in mild oxidative stress in Drosophila melanogaster. Redox Report., 2017, 22(3), 137-146.
49. Strilbytska O., Semaniuk U., Storey K., Edgar B., Lushchak O*. Activation of TOR/MYC signaling axis in intestinal stem and progenitor cells affects longevity, stress resistance and metabolism in Drosophila. Comp. Biochem. Physiol., 2017, 203, 92-99.
48. Kubrak O., Lushchak O., Meet Zandawala M., Nässel D. A novel GnRH-like signaling to adipocytes modulates stress responses and metabolism in Drosophila. Open Biol., 2016, 11, 160152.
47. Lushchak O*., Gospodaryov D., Yurkevych I. Oxidized lipids did not reduce lifespan in the fruit fly, Drosophila melanogaster. Arch. Insect Biochem. Physiol., 2016, 91, 52-63.
46. Rovenko B., Kubrak O., Gospodaryov D., Perkhulyn N., Yurkevych I., Sanz A., Lushchak O**., Lushchak V. High sucrose consumption promotes obesity whereas its low consumption induces oxidative stress in Drosophila melanogaster. J. Insect Physiol., 2015, 79, 42-54.
45. Rovenko B., Kubrak O., Gospodaryov D., Yurkevych I., Sanz A., Lushchak O**., Lushchak V. Restriction in glucose and fructose causes mild oxidative stress independently of mitochondrial activity and reactive oxygen species in Drosophila melanogaster. Comp. Biochem. Physiol., 2015, 187, 27-39.
44. Lushchak O., Carlsson M., Nässel D. Food odors trigger an endocrine response that affects food ingestion and metabolism. Cell. Mol. Life Sci., 2015, 72, 3143–3155.
43. Perkhulyn N., Rovenko B., Zvarych T., Lushchak O., Storey J., Storey K., Lushchak V. Sodium chromate demonstrates some insulin-mimetic properties in the fruit fly Drosophila
melanogaster. Comp. Biochem. Physiol., 2015, 167, 74-80.
42. Rovenko B., Perkhulyn N., Gospodaryov D., Sanz A., Lushchak O**., Lushchak V. High fructose consumption rather than glucose promotes diet-induced obese phenotype in Drosophila melanogaster. Comp. Biochem. Physiol., 2015, 180, 75-85.
41. Gospodaryov D., Lushchak O., Rovenko B., Perkhulyn N., Gerards M., Tuomela T., Jacobs H. Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. Biochem. Biophys. Acta, 2014, 1837(11), 1861-1869.
40. Luo J., Lushchak O., Goergen P., Williams M., Nässel D. Drosophila insulin-producing cells are differently modulated by serotonin and octopamine receptors and affect aggressive behavior. PLoS one, 2014, 9(6), e99732.
39. Rovenko B., Perkhulyn N., Lushchak O., Storey J., Storey K., Lushchak V. Molybdate partially mimics insulin-promoted metabolic effects in Drosophila melanogaster. Comp. Biochem. Physiol., 2014, 165, 76-82.
38. Lushchak O*., Gospodaryov D., Rovenko B., Yurkevych I., Perkhulyn N., Lushchak V. Specific dietary carbohydrates differentially influence the lifespan and fecundity of Drosophila melanogaster. J Gerontol., 2014, 69(1), 3-12.
37. Rovenko B., Lushchak V., Lushchak O. Carbohydrate restriction in the larval diet causes oxidative stress in adult insects of Drosophila melanogaster. Ukr. Biochem. J., 2013, 85(5), 61-72.
36. Lozinsky O., Lushchak O., Storey J., Storey K., Lushchak V. The mitochondrial uncoupler 2,4-dinitrophenol attenuates sodium nitroprusside-induced toxicity in Drosophila melanogaster: Potential involvement of free radicals. Comp. Biochem. Physiol., 2013, 158(4), 244-52.
35. Lozinsky O., Lushchak O., Lushchak V. 2,4-dinitrophenol partially alleviates ferrocyanide induced toxicity in Drosophila melanogaster. Arch. Insect Biochem. Physiol., 2013, 84(3), 157-73.
34. Gospodaryov D., Yurkevych I., Lushchak O**., Lushchak V. Lifespan extension and delay of age-related functional decline caused by Rhodiola rosea depends on dietary macronutrient balance. Longevity & Healthspan, 2013, 2:12.
33. Lozinsky O., Lushchak O., Kryshchuk N., Shchypanska N., Riabkina A., Skarbek S., Maksymiv I., Storey J., Storey K., Lushchak V. S-nitrosoglutathione-induced toxicity in Drosophila melanogaster: Delayed pupation and induced mild oxidative/nitrosative stress in eclosed flies. Comp. Biochem. Physiol., 2013, 164(1), 162-170.
32. Kapan N., Lushchak O., Luo J., Nässel D. Identified peptidergic neurons in the Drosophila brain regulate insulin-producing cells, stress responses and metabolism by coexpressed short neuropeptide F and corazonin. Cell. Mol. Life Sci., 2012, 69(23), 4051-4066.
31. Rovenko B., Lushchak O*., Lozinsky O., Kubrak O., Lushchak V. Mild oxidative stress in fruit fly Drosophila melanogaster induced by sucrose. Ukr. Biochem. J., 2012, 84 (5), 97-105.
30. Lozinsky O., Lushchak O., Lushchak V. Sodium nitroprusside toxicity in Drosophila melanogaster: delayed pupation, reduced adult emergence, and induced oxidative/nitrosative stress in eclosed flies. Arch. Insect Biochem. Physiol., 2012, 80(3), 166-185.
29. Lushchak O*., Gospodaryov D., Rovenko B., Glovyak A., Yurkevych I., Klyuba V., Shcherbij M., Lushchak V. Balance between macronutrients affects lifespan and functional senescence in fruit fly Drosophila melanogaster. J. Gerontol. A Biol. Sci., 2012, 67(2), 118-125.
28. Lushchak O., Rovenko B., Gospodaryov D., Lushchak V. Drosophila melanogaster larvae fed by glucose and fructose demonstrate difference in oxidative stress markers and antioxidant enzymes of adult flies. Comp. Biochem. Physiol., 2011, 160(1), 27-34.
27. Kubrak O., Lushchak O., Lushchak J., Torous I., Storey J., Storey K., Lushchak V. Chromium effects on free radical processes in goldfish tissues: Comparison of Cr(III) and Cr(VI) exposures on oxidative stress markers, glutathione status and antioxidant enzymes. Comp. Biochem. Physiol., 2010, 152, 360-370.
26. Lushchak O., Inoue Y., Lushchak V. Saccharomyces cerevisiae exhibits a Yap1-mediated adaptive response to SNP-induced stress. Biochemistry (Moscow), 2010, 75(5), 629-635.
25. Lushchak O., Bahniukova T., Lushchak V. Activation of enzymes of soxRS-regulon by hydrogen peroxide in Escherichia coli. Microbiol. J., 2009, 71 (1), 22-27
24. Lushchak O., Bayliak M., Korobova O., Levine R., Lushchak V. Buffer modulation of menadione-induced oxidative stress in Saccharomyces cerevisiae. Redox Report, 2009, 14(5), 214-220.
23. Lushchak O., Kubrak O., Storey J., Storey K., Lushchak V. Low toxic herbicide Roundup induces mild oxidative stress in goldfish tissues. Chemosphere, 2009, 76 (7), 932-937.
22. Lushchak O., Kubrak O., Lozinsky O., Storey J., Storey K., Lushchak V. Chromium(III) induces oxidative stress in goldfish liver and kidney. Aquat. Toxic., 2009, 93, 45–52.
21. Lushchak O., Lushchak V. Possible pathways involved in activation of catalase and superoxide dismutase in yeast S. сerevisiae treated with sodium nitroprusside. Ukr. Biochem. J., 2009, 81 (2), 26-31.
20. Lushchak O., Kubrak O., Torous I., Nazarchuk T., Storey K., Lushchak V. Trivalent chromium induces oxidative stress in goldfish brain. Chemosphere, 2009, 75, 56-62.
19. Semchuk N., Lushchak O., Nazarchuk T., Falk J., Krupinska K., Lushchak V. Inactivation of genes, encoding tocopherol biosynthesis pathways enzymes, results in oxidative stress in outdoor grown Arabidopsis thaliana. Plant Physiol. Biochem., 2009, 47(5), 384-390.
18. Lushchak O., Nykorak M., Ohdat T., Inoue Y., Lushchak V. Inactivation of superoxide dismutase encoding genes modifies yeast cell response to S-nitrosoglutathione induced stress. Biochemistry (Moscow), 2009, 74(4), 550-557.
17. Lushchak O., Lushchak V. Catalase modifies yeast Saccharomyces cerevisiae response toward S-nitrosoglutathione-induced stress. Redox Report, 2008, 13(6), 283-291.
16. Semchuk N., Lushchak O., Falk J., Krupinska K., Lushchak V. Effects of VTE1 and VTE4 gene inactivation of salt stress response in Arabidopsis thaliana. Ukr. Biochem. J., 2008, 80 (3), 48-54.
15. Lushchak O., Kubrak O., Nykorak M., Storey K., Lushchak V. The effect of potassium dichromate on free radical processes in goldfish: Possible protective role of glutathione. Aquat. Toxic., 2008, 87, 108–114.
14. Lushchak O., Lushchak V. Sodium nitroprusside induces mild oxidative stress in Saccharomyces cerevisiae. Redox Report, 2008, 13(4), 144-152.
13. Lushchak O., Lozinsky O., Nazarchuk T., Lushchak V. S-nitrosoglutathione induces nitrosative stress in yeast: modified role of catalase. Ukr. Biochem. J., 2008, 80 (2), 84-91.
12. Kubrak O., Lushchak O., Lushchak V. Comparative characteristics of lactate dehydrogenase from the liver and white muscles of common carp (Cyprinus carpio). Ukr. Biochem. J., 2008, 80 (4), 35-41.
11. Lushchak O., Semchyshyn H., Lushchak V. Growth on ethanol results in coordinated yeast S. cerevisiae cell response on inactivation of genes encoding superoxide dismutases. Redox Report, 2007, 12(4), 181-188.
10. Bagnyukova T., Lushchak O., Storey K., Lushchak V., Oxidative stress and antioxidant defense responses by goldfish tissues to acute change of temperature from 3 to 23ºC. J. Thermal Biol., 2007, 32, 227-234
9. Mandryk S., Lushchak O., Semchyshyn H., Lushchak V. Role of Cu,Zn- and Mn-containing superoxide dismutases in yeast cell during growth on ethanol. Microbiol. J. (Ukr), 2007, 69(2), 35-42.
8. Lushchak V., Bagnyukova T., Lushchak O., Storey J., Storey K. Diethyldithiocarbamate injection induces transient oxidative stress in goldfish tissues. Chem.-Biol. Interact., 2007, 170(1), 1-8.
7. Lushchak O., Müller S., Mair T. Comparison of glycolytic NADH oscillations in yeasts Saccharomyces cerevisiae and Saccharomyces carlsbergensis. Ukr. Biochem. J., 2006, 78(5), 22-28.
6. Lushchak V., Semchyshyn H., Mandryk S., Lushchak O. Possible role of superoxide dismutases in the yeast Saccharomyces cerevisiae under respiratory conditions. Arch. Biochem. Biophys., 2005, 441, 35-40.
5. Lushchak V., Semchyshyn H., Lushchak O., Mandryk S. Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells. Biochem. Biophys. Res. Commun., 2005, 338, 1739-1744.
4. Lushchak V., Bagnyukova T., Husak V., Luzhna L., Lushchak O., Storey K. Hyperoxia results in transient oxidative stress and an adaptive response by antioxidant enzymes in goldfish tissues. Int. J. Biochem. Cell Biol., 2005, 37, 1670-1680.
3. Lushchak V., Bagnyukova T., Lushchak O., Storey J., Storey K. Hypoxia and recovery perturb free radical processes and antioxidant potential in common carp (Cyprinus carpio). Int. J. Biochem. Cell Biol., 2005, 37, 1319-1330.
2. Lushchak V., Bagnyukova T., Lushchak O. Indices of oxidative stress. 1. TBA-reactive substances and carbonylproteins. Ukr. Biochem. J., 2004, 76 (3), 136-141.
1. Lushchak O., Bagnyukova T., Lushchak V. The effect of aminotriazole on the activity of catalase and glucose-6-phosphate dehydrogenase of two frog species – Rana ridibunda and R. esculenta. Ukr. Biochem. J., 2003, 75 (4), 45-50.
Reviews and book chapters
44. Vaiserman A., Lushchak O. Zayachkivska A., Koliada A. “Curcumin” In: “Antiaging pharmacology” Ed. A. Vaiserman. 2022. In press.
43. Piskovatska V., Buheruk V., Stilbytska O., Zayachkivska A., Lushchak O.* “Nonsteroidal Anti-Inflammatory Drugs” In: “Antiaging pharmacology” Ed. A. Vaiserman. 2022. In press.
42. Strilbyska O., Tsiumpala S., Kozachyshyn I., Strutynska T., Burdyliuk N., Lushchak V., Lushchak O.* The effects of low-toxic herbicide Roundup and glyphosate on mitochondria. EXCLI J. 2022, 21:183-196.
41. Vaiserman A., Lushchak O.* Prenatal famine exposure and adult health outcomes: an epigenetic link. Environ. Epigenet. 2021, 7(1):dvab013.
40. Lushchak V., Lushchak O. Interplay between reactive oxygen and nitrogen species in living organisms. Chem-Biol. Interact. 2021, 349:109680.
39. Kamyshnyi O., Matskevych V., Lenchuk T., Strilbytska O., Storey K., Lushchak O.* Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential. Biomed. Pharmacother. 2021, 144:112230.
38. Vaiserman A., Lushchak O.* DNA methylation changes induced by prenatal toxic metal exposure: An overview of epidemiological evidence. Environ. Epigenet. 2021, 7(1):dvab007.
37. Peteliuk V., Rybchuk L., Bayliak M., Storey K., Lushchak O.* Natural sweetener Stevia rebaudiana: Functionalities, health benefits and potential risks. EXCLI J. 2021, 20:1412-1430.
36. Semaniuk U., Strilbytska O., Malinovska K., Storey K., Vaiserman A., Lushchak V., Lushchak O.* Factors that regulate expression patterns of insulin-like peptides and their association with physiological and metabolic traits in Drosophila. Insect Biochem Mol Biol. 2021, 135:103609.
35. Vaiserman A., Lushchak O., Koliada A., “Environmental epigenetic epidemiology” In: Medical Epigenetics (Second Edition). Ed. T. Tollefsbol, Academic Press. 2021, 11-31.
34. Heier C., Klishch S., Stilbytska O., Semaniuk U., Lushchak O.* The Drosophila model to interrogate triacylglycerol biology. Biochim. Biophys. Acta Mol. Cell. Biol. Lipids. 2021, 1866(6):158924.
33. Vaiserman A., Koliada A., Lushchak O. Phyto-nanotechnology in anti-aging medicine. Aging (Albany NY). 2021. doi: 10.18632/aging.203026
32. Lushchak O.*, Piskovatska V., Strilbytska O., Kindrat I., Stefanyshyn N., Koliada A., Bubalo V., Storey K., Vaiserman A. Aspirin as a Potential Geroprotector: Experimental Data and Clinical Evidence. Adv. Exp. Med. Biol. 2021, 1286:145-161.
31. Semaniuk U., Piskovatska V., Strilbytska O., Strutynska T., Burdyliuk N., Vaiserman A., Bubalo V., Storey K.B., Lushchak O.* Drosophila insulin-like peptides: from expression to functions – a review. Entomol. Exp.s Appl. 2021, 169(2):195-208.
30. Vaiserman A., Koliada A., Zayachkivska A., Lushchak O. Curcumin: A therapeutic potential in ageing-related disorders. PharmaNutrition. 2020, 14:100226.
29. Vaiserman A., Koliada A., Lushchak O., Castillo M. Repurposing drugs to fight aging: The difficult path from bench to bedside. Med. Res. Rev. 2020, doi: 10.1002/med.21773.
28. Vaiserman A., Koliada A., Lushchak O. Neuroinflammation in pathogenesis of Alzheimer’s disease: Phytochemicals as potential therapeutics. Mech. Ageing Dev. 2020, 189:111259.
27. Kamyshnyi A., Krynytska I., Matskevych V., Marushchak M., Lushchak O. Arterial Hypertension as a Risk Comorbidity Associated with COVID-19 Pathology. Int. J. Hypertens. 2020:8019360.
26. Vaiserman A, Koliada A, Zayachkivska A, Lushchak O.** Nanodelivery of natural antioxidants: an anti-aging perspective. Front. Bioeng. Biotech. 2020, 7, 447.
25. Lushchak O., Karpenko R., Zayachkivska A., Koliada A., Vaiserman A. “Lipid-based nano-delivery of phytobioactive compounds in anti-aging medicine” in Systemic Delivery Technologies in Anti-Aging Medicine: Methods and Applications, Springer-Nature, 2020, in press.
24. Vaiserman A., Lushchak O. “Health and pro-longevity interventions” in Explaining Health Across the Sciences. Springer-Nature. 2020, 473-495.
23. Piskovatska V., Storey K., Vaiserman A., Lushchak O*. The use of metformin to increase the human healthspan. Adv. Exp. Med. Biol., 2020, 1260, 319-332.
22. Lushchak O.,* Strilbytska O., Koliada A., Zayachkivska A., Burdyliuk N., Yurkevych I., Storey K., Vaiserman A. Nanodelivery of phytobioactive compounds for treating aging-associated disorders. Geroscience, 2020, 42, 117-139.
21. Lushchak O.,* Strilbyska O., Piskovatska V., Koliada A., Storey K. “Intermittent Fasting” in Encyclopedia of Biomedical Gerontology, Elsevier, 2019.
20. Piskovatska V., Strilbyska O., Storey K., Vaiserman A., Lushchak O.* “mTOR Pharmacology” in Encyclopedia of Biomedical Gerontology, Elsevier, 2019.
19. Vaiserman A., Lushchak O. “Geoscience” in Encyclopedia of Biomedical Gerontology, Elsevier, 2019.
18. Vaiserman A., Lushchak O. Developmental origins of type 2 diabetes: Focus on epigenetics. Ageing Res. Rev., 2019, 55:100957.
17. Vaiserman A., Lushchak O. Prenatal Malnutrition-Induced Epigenetic Dysregulation as a Risk Factor for Type 2 Diabetes, Int. J. Genomics, 2019, 3821409.
16. Piskovatska V., Strilbytska O., Koliada A., Vaiserman A., Lushchak O.* Health Benefits of Anti-aging Drugs. Subcell. Biochem. 2019, 91, 339-392.
15. Lushchak O.,* Strilbytska O., Yurkevych I., Vaiserman A., Storey KB. Implications of amino acid sensing and dietary protein to the aging process. Exp. Gerontol. 2019, 115, 69-78.
14. Piskovatska V., Stefanyshyn N., Storey K., Vaiserman A., Lushchak O.* Metformin as a geroprotector: experimental and clinical evidence. Biogerontology. 2019, 20, 33-48.
13. Vaiserman A., Lushchak O. “Early-Life Adjustment of Epigenetic Aging Clock”. Part of the Healthy Ageing and Longevity book series, Early Life Origins of Ageing and Longevity, 2019, 269-282.
12. Vaiserman A., Koliada A., Lushchak O. Developmental programming of aging trajectory. Ageing Research Reviews. 2018., 47, 105-122.
11. Lushchak O.,* Zayachkivska A., Vaiserman A. Metallic nano-antioxidants as potential therapeutics for diabetes-induced oxidative stress: A translational perspective Oxid. Med. Cell. Longev., 2018, 3407375.
10. Vaiserman A., Koliada A., Lushchak O. “Epigenetic Programming of Human Disease and Aging” In: Epigenetics in Human Disease (Second Edition). Ed. T. Tollefsbol, Elsevier. 2018, 975-992.
9. Vaiserman A., Lushchak O., Koliada A. “Epigenetics of Longevity in Social Insects” In: “Epigenetics of aging and longevity” Eds. A. Moskalev, A. Vaiserman. Academic Press. 2018, 271-292.
8. Lushchak O*., Strilbytska O., Piskovatska V., Storey K., Koliada A., Vaiserman A. The role of TOR pathway in mediating the link between nutrition and longevity. Mech. Aging Dev., 2017, 164, 127-138.
7. Vaiserman A., Lushchak O. Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives. J. Transl. Med. 2017, 15(1), 160.
6. Vaiserman A., Lushchak O., Koliada A. Anti-aging pharmacology: promises and pitfalls. Ageing Research Reviews. 2016, 31, 9-35.
5. Vaiserman A. and Lushchak O. “Anti-aging Drugs: Where We Are and Where We are Going?” In: “Anti-aging drugs: from basic research to clinical practice” Ed. A. Vaiserman. Royal Society of Chemistry. 2016, 1-10.
4. Lushchak O.* and Gospodaryov D. “Mimetics of Caloric Restriction” In: “Anti-aging drugs: from basic research to clinical practice” Ed. A. Vaiserman. Royal Society of Chemistry. 2016, 229-271.
3. Lushchak. O., Piroddi M., Galli F., Lushchak V. Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling and metabolism of reactive oxygen species. Redox Report, 2014, 19 (1), 8-15.
2. Nässel D., Kubrak O., Liu Y., Luo J., Lushchak O. Factors that regulate insulin producing cells and their output in Drosophila. Front. Physiol., 2013, 4, art. 252.
1. Lushchak, V.I., Semchyshyn, H.M. and Lushchak, O.V. “The Classic Methods to Measure Oxidative Damage: Lipid Peroxides, Thiobarbituric-Acid Reactive Substances, and Protein Carbonyls” In “Oxidative Stress in Aquatic Ecosystems” Eds D. Abele, J. P. Vázquez-Medina and T. Zenteno-Savín, 2011, John Wiley & Sons, Ltd, Chichester, UK.
Patents
3. Michels Birgit, …. Lushchak O, …. Gerber B., 2020, Compound for use in the increasing of mental capacity. United States Patent and Trademark Office, US20200360332.
2. Michels Birgit, …. Lushchak O, …. Gerber B., 2020, Compound for use in the increasing of mental capacity [Verbindung zur anwendung bei der steigerung von mentaler leistungsfähigkeit] European Patent, EP3713604.
1. Michels Birgit, …. Lushchak O, …. Gerber B., 2019, Compound for use in the increasing of mental capacity/Verbindung zur anwendung bei der steigerung von mentaler leistungsfähigkeit, Patent Cooperation Treaty Application, WO2019101952.