Scientists of the Department published the article on the effect of a high-calorie diet on the brain

The research on the effects of diet and oxidative stress on mouse behavior is now published in BBA General Subjects. It is part of Mariia Bayliak’s project supported by NRF Ukraine and represents our first work combining RT-qPCR and behavioral tests.

The study shows that a high-calorie diet with elevated fat and fructose content induces both anxious behavior and increased motor activity simultaneously. These physiological changes are accompanied by the development of oxidative stress in the brain and a restructuring of energy metabolism. The addition of α-ketoglutarate to the high-calorie diet attenuated the changes caused by this dietary pattern.

The study was supported by the grant from the National Research Foundation of Ukraine (project number 2020.02/0118).