Research project: Cellular mechanisms of healthy brain ageing under caloric restriction
Research grant supported by Volswagenstiftung Foundation (German)
| Duration | Feb 15, 2016 – Feb15, 2020 |
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Project web-site: http://portal.volkswagenstiftung.de/search/projectDetails.do?ref=90233
Partners:
Universitäts klinikum Tübingen, Medizinische Fakultät, Physiologisches Institut, Tübingen
Vasyl Stefanyk Precarpathian National University,Department of Biochemistry and Biotechnology, Ivano-Frakivsk, Ukraine
Professor of neurophysiology at the University of Manchester
Project description
Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be adressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-mimetics for future therapies. This project is expected to produce fundamental knowledge on the effects of ageing on neurons, astrocytes and microglia both in vitro and in vivo and on the mechanisms underlying caloric restriction-based improvement of their function. Based on the data obtained one shall be able to identify critical cellular/molecular pathways that can be targeted by CR-mimetics for future therapies.