Grant from Volswagenstiftung Foundation

Research project: Cellular mechanisms of healthy brain ageing under caloric restriction


Research grant supported by Volswagenstiftung Foundation (German)

Initiative: Trilateral Partnerships – Cooperation Projects between Scholars and Scientists from Ukraine, Russia and Germany (completed)
Allocation: Feb 15, 2016
Period of funding: 3 Years

Project web-site:


Prof. Dr. Olga Garaschuk

Universitäts klinikum Tübingen, Medizinische Fakultät, Physiologisches Institut, Tübingen

Prof. Dr. Volodymyr Lushchak

Vasyl Stefanyk Precarpathian National University,Department of Biochemistry and Biotechnology, Ivano-Frakivsk, Ukraine

Prof. Dr. Alexei Verkhratsky

Staatliche Universität Nizhny Novgorod, Laboratory of Neuronal-glial interactions, in health and disease, Nizhny Novgorod, Russia

Prof. Dr. Alexey Semyanov

Staatliche Universität Nizhny Novgorod, Institute of Biology and Biomedicine, Nizhny Novgorod, Russia

Project description

Using biochemical, electrophysiological and in vivo/in situ imaging approaches the following specific aims will be adressed: 1) Characterization of the biochemical (energetic balance, efficiency of glycolysis and mitochondrial function, oxidative stress intensity) and physiological (at the single cell and network level) status of the ageing brain. 2) Comparison of the extent of ageing-induced deregulation of brain function in control and CR animals. 3) Deciphering cellular/molecular mechanisms underlying beneficial effects of CR, identification of pathways that can be targeted by CR-mimetics for future therapies. This project is expected to produce fundamental knowledge on the effects of ageing on neurons, astrocytes and microglia both in vitro and in vivo and on the mechanisms underlying caloric restriction-based improvement of their function. Based on the data obtained one shall be able to identify critical cellular/molecular pathways that can be targeted by CR-mimetics for future therapies.